Herbal Pharm Rx and Tweedle Farms Sample Products

Recently, we were sent a bunch of samples from Herbal Pharm Rx and Tweedle Farms. A myriad of CBD isolate, flower, CBG and other rubs, ointments, edibles, buds, doggie treats, pre-rolls, wax and combination tinctures besides CBG isolate and CBN oil.

I had started to review each Tweedle Farms product but decided to put them all in this posting.

Every flower based product received from Tweedle Farms came in above what we are used to getting locally. The pre-rolls were all superb in strains such as Lifter, Suver Haze, Elektra and a 1 gram wax/shatter that only added to the strength of cone or the smokeable you choose to use it with. Every product was above 18% CBD concentration with rich terpene profiles and a great number of Cannabinoids for all their given purposes. If you want a great site for raw flower in any size in many strains with full information about each strain, this is a great site for you. The wax is an almost given purchase with any flower or even in its own. All lab reports are right there on the website as they are very transparent and don’t hide anything from current or new customers.

The CBG:CBD tincture was great since it was only a 15ml tester it didn’t last too long for me but was excellent in numerous ways. I had excellent sleep falling into deep sleep for more than 3 hours a night which I normally don’t do for more than 30 minutes a night. In addition to the amount of sleep, my generalized anxiety was way lower when stressed out at work and my pain level was incredibly manageable with NO painsomnia in its combination of 20:1 CBD to CBG of 250mg CBD only and I require way more CBD than that normally so the blend of CBG was indeed perfect which goes to show you that you do not require much CBD when there is CBG mixed in the tincture in a 10 or 20:1 combination where 20:1 is most common. So to make it last, after I used up the 250mg 15ml tincture, I bought the 30ml 1000mg CBD:CBG tincture and it’s lasted well over 2 months so far and again, I’m in deep sleep far more than I’m used to with all the extra added benefits of high concentration full spectrum CBD oil.

Now with Herbal Pharm Rx, we received many a product to test and possibly carry in the future. In no particular order, we received 2 unnamed 1 gram pre-rolls in nice sturdy wrapping to both keep them fresh and protected from bends or kinks, 1 1000mg CBD freeze balm good for deep massage without getting all over your hands and not coming off. If you place it on sinus cavity exit points and trigger point and rub it in, it helps with sinus headaches, Occipital Neuralgia related headaches and any other things you can think would benefit from a CBD pain-relieving freeze balm. Then we got a 2000mg CBD roll-on with menthol it feels like and is excellent for topical application for muscle joint and nerve pain with a higher CBD concentration than the balm. It’s a large 3oz bottle with a roll on applicator. It says to use up to 6 times a day, I think 4-5 is enough for me which means 4 for the average person without a chronic pain issue. The next product is a 5000mg CBD isolate tincture in Lemon in MCT oil that is great for everything and at 5000mg, 30ml will last you forever. That’s 166.6mg per dose (per ml basically) so each dose is between 100 and 150mg as you never get a full pull on the tincture. The next product is a 30 pill 300mg CBD bottle labeled Sleep where each pill is 10mg with added 3mg of melatonin. Now you know I’m not a fan of supplementing melatonin because the more you supplement the less your body makes naturally but during winter months, having the extra 3mg is beneficial as there is far less sunlight to help your body synthesize vitamin D into melatonin. Personally I take 2 tablets during the winter months for that added benefit. The next product were all natural doggie treats that are 10mg each that you can eat if you wanted as there are no surprise ingredients in them. I don’t have a dog so I have them to my cousin who has a dog and he said that their dog has been calmer and more relaxed and less rambunctious but they usually give him 2 at a time. To me I think it’s better to take a doggie treat versus oil because it’s hard to get a dog to keep it under their tongue for extended periods so it fully works… The last product is an Awake formula that is 30 pills, 25mg CBD per pill and 200mg caffeine per pill as well. As someone with afib, 200mg is just too much for me so I’m giving this bottle to one of my coffee loving work mates and have them review them for me. The person I have in mind loves their coffee do much that they would probably open up the capsule and mix it into a large cup of already strong coffee. So if you are waiting for a review of that, I’ll have it soon. And the last product is both a novelty and good for tea: CBD honey sticks. Each pack is 10 10mg CBD honey sticks and they are very sweet, organic and make any tea that much better with just the perfect amount of CBD.

I am awaiting a package of CBN from another company so stick around as I’ll have that soon with an accompanied review soon after.

Be well.

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BLACK FRIDAY 30% SITE WIDE SALE AT CBDISTILLERY.COM

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To access this sale, use the link below and enter the coupon “BLACKFRIDAY30” at checkout.

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Terpenes: Specific Profiles and Isolates For Specific Pain Problems.

Pain, inflammation, stiffness, overuse, cancer, illness, wasting, referred from, referred to, localized, radicular, neuralgia, neuropathy, injury, misspent youths, athletes, whatever you call it or refer to it as, pain is just like this list: all different. All with different causes, grades, illnesses, uses, over use, referred from one location to another another, so you wonder why there are so many different kinds of opioids on the market.

Before I continue I will agree with the general consensus: this country has an opioid problem. It’s not the patients fault unless, of course, that patient has drug selling behaviours no one had picked up before making them a great actor and mind you, doctors are excellent at finding these patients and denying them opioids because whatever pain they have is Tylenol worthy. Not Dilaudid worthy. Not tramadol worthy. Not hydrocodone, oxycodone, codeine, buprenorphine, Suboxone, methadone, fentanyl, morphine, etc, worthy. So these users either realize that immediately or become statistics either via heroin ODs or other synthetic variants made in bathtubs that are 100 times more potent than transdermal fentanyl.

So if opioids isn’t the answer for you then what is? One word: Terpenes (either profiles or isolates).

There is one common misconception about terpenes: they are derived from the Cannabis plant be it hemp or Marijuana.

This is 100% untrue. As you know, cannabis – hemp or Marijuana – are plants, AKA botanicals. The Terpenes I use personally and put in our pain products are botanical terpene isolates but not from any plant in the cannabis species. The terpene isolates I use are from plants heavy in specific terpinoids, not plants that are high in one and low in another hence why we use Isolates: only one specific terpene from any one botanical.

There are a handful of Terpene isolates that are amazing at pain control, that aren’t expensive at all and can be made into a fully Entourage inducing product by using CBD isolate with added terpene isolates to complete the solution.

The list of Terpene Isolates that are great for both pain and inflammation are the following:

  • Myrcene – A study done just this year revealed that it’s uses as an anti-inflammatory and for treating pain from migraine and arthritis are exceptionally great for an herbal botanical ingredient.
  • Pinene – Also called Alpha-Pinene, is also a great anti-inflammatory which is also great for the immune and respiratory systems.
  • Linalool – Studied as a potent antioxidant, it’s properties Target the immune system and halt it’s inflammatory response.
  • Humulene – Proven to be an effective anti-inflammatory, antibacterial, appetite suppressant and anti-tumor.
  • Beta-Carophyllene – Shown to be an analgesic, anti-inflammatory, anti-cancer, anti-anxiety and anti-depressant.
  • Limonene – Promotes weight loss, prevents cancer, treats cancer, and treats bronchitis
  • Terpinolene – Good as a mild sedative and can reduce anxiety. Anything that is good at reducing anxiety is often used to help with musculoskeletal pain like how they prescribe Valium for this sort of pain in the cervical spine.

For relaxation, a combination of Myrcene, Linalool, Terpinolene and Beta-Carophyllene can help aid insomniacs when mixed in the right combinations.

Personally, due to my pain from a degenerating c-spine, in forced to be on heavy non-impairing narcotics namely the transdermal 3 day fentanyl patch and oxycodone (Percocet). I supplement the extra pain I have that’s left over with terpenes, CBD and CBG combinations. U can always ask for an increase in the fentanyl dose but instead I go the natural route and find it to be highly beneficial due to the other effects it offers the human body.

I use the product “Elevation Terpenes” which can be found in Amazon for 15 dollars USD for small amounts but remember, you should be taking small quantities of terpenes for their effects versus trying to drown out your pain and insomnia with extra amounts of terps. Your body and it’s CB1 and CB2 receptors in your ECS can only transmit and metabolize so much at once.

Your initial investment for CBD isolate based solutions are 20 to 60 dollars of CBD isolate powder depending on how much you buy at once, each one of 4 terpenes are $15 on Amazon so that’s approximately $120 as an initial investment. I generally put in 1/2 gram per 1/2 gram of coconut oil, and 1-2 milligrams of each terpenes into a small jar. The only thing I would say you can change without ruining the broth is how much CBD isolate you decide to use, 1/2 gram versus 1 gram. Obviously there is more concentrated CBD in 1 gram versus 1/2 gram. To add CBG, add about 20-50 drops from a 30ml bottle which contains 1000mg total of CBG. Adding CBN is an option but it’s harder to find and then find at recent prices.

The concoction above is good for oral ingestion (sublingual) if the Terpenes you buy are dietary kinds such as the brand I mentioned.

What you see above is an option to either complete your pain management solution with narcotic usage or to replace it altogether.

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CBG – The Mother of All Cannabinoids. Why?

So you’ve heard me or another author write “CBG aka the mother of all Cannabinoids” and wonder what exactly that means because there, as you know, are many cannabinoids starting at THC and CBD and then the sub cannabinoids like CBC, CBN, etc.

What is CBG? CBG stands for cannabigerol. Found naturally in marijuana, it is the precursor molecule of both CBD and THC.

During growth of the cannabis plant, CBG is continuously converted to THC and CBD via specific enzymes in each plant activated by light, heat, moisture, humidity, pressure, nutrition, stress, etc and converted to literally every known cannabinoid.

During this cannabinoid life cycle, it’s concentration hovers around 1% which is about 20 times lower than the cannabinoid THC. The lower the concentration of CBG makes it harder for those to find the exact efficacy of CBG.

CBG-CBN-THC-CBC bio-synthesis 1= cannabigerol (CBG); 2 = cannabidiol (CBD); 3 = cannabichromene (CBC); 4 = delta-9-tetrahydrocannabinol (THC).

Above is the life cycle of CBG and how natural enzyme reactions and effects of chlorophyll help CBG become CBD, CBC and THC.

Cannabinoids THC, CBD and others like CBG have been found to work much better together than in an isolated form (isolate versus broad or full spectrum for example). Synergistic effects and interrelationships are very important in medicine, however, mainstream pharmaceutical practice generally ignores this fundamental by offering a new medication that is more of an isolate with a broader reach of effects than a combination of 2 medications to fulfill your neurotransmitters and endocannabinoid system receptors CB1 and CB2 but this mostly has to do with fulfilling the entourage effect.

Specifically:
CBG does not trigger THC-like activity in rodents and primates, verifying that it is not an intoxicant, not psychoactive. In rodent models, CBG taken alone in high doses (80 mg/Kg – comparitively a rather high dose) did not promote locomotor suppression (depressed motor skills), catalepsy (extreme couch lock), hypothermia or analgesia (medicinal marijuana pain relief). So you can’t assign any psychoactive effects on cannabigerol in any dose to any motor or neurological system yet. Researchers need natural CBG in much higher concentrations in natural forms. But the one thing we know for sure is that both CB1 and CB2 are activated by CBG, not either/or, making adding CBG to any single isolate or broad spectrum to full spectrum product simply due to cross transmission in your endocannabinoid system’s receptors beneficial. Example: a high CBD isolate may effect CB1 while adding CBG to the mix would have an effect on CB2, doubling up on the effect of 2 Cannabinoids taken by two different angles affecting all ECS receptors is the definition of entourage effect.

I know that is all quite technical but if you read it twice or thrice and understand the body’s ECS it makes perfect sense.

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CBG EFFICACY – SUMMARY OF RESEARCH FINDINGS

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Pain

CBG has shown potential for alleviating neuropathic, inflammatory and other pain in animal studies. CBG might even have a higher efficacy than CBD. CBG can modulate the uptake of GABA in the brain (most of you are familiar with gabapentin/neuronten for example), to decrease anxiety and reduce muscle tension. GABA’s principal role is to reduce neuronal excitability throughout the nervous system. GABA is also directly responsible for the regulation of muscle tone.

Anxiety

Lab tests showed that CBG is an antidepressant similar to imipramine. Imipramine, or Tofranil is a tricyclic pharmaceutical antidepressant. It is mainly used in the treatment of major depression and enuresis. Being a cannabinoid, CBG’s safety profile is extremely high, making it a candidate to replace pharmaceuticals with a multitude of toxic side effects.

CANNABIGEROL (CBG) - BETTER THAN CBD?

CANNABIGEROL (CBG) – BETTER THAN CBD?

Inflammation, digestive conditions

It has been shown to improve inflammatory bowel disease,ulcerative colitis and Crohn’s disease in lab findings. Obviously, this promising finding invites clinical study in humans.

Skin conditions

CBG boosts the body’s natural skin moisturizers, holding promise for dry-skin syndromes and promotes full hydration, which makes the face look much younger.

Neuroprotection

CBG has neuroprotective properties, with hypothetical efficacy in the treatment of neurodegenerative diseases from Huntington’s disease and multiple sclerosis (MS) to Alzheimer’s, ALS, Parkinson’s, dementia and others to make a few.

Cancer

CBG is showing promising properties in vitro for the potential treatment of a broad range of cancers, including breast, liver, lung, pancreatic, skin, ovarian, renal, bladder and colon cancer as well as malignancies that turn metastatic. It is thought to believe that CBG has anti-angiogenesis benefits (cuts off the blood supply to the cancers or tumors killing then from the inside out without toxic side effects of chemo or radiation. (See also Rick Simpson Oil aka RSO).

Glaucoma

Cannabigerol has been shown to relieve intraocular pressure, which is the cause of glaucoma.

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CBG INTO THE FUTURE

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Cannabis alchemists round the world are seeking to produce high CBG strains, using selective breeding combined with genetic testing. It would seem that efforts would focus primarily on the shutting down the enzyme system that converts CBG into THC or CBD full stop. There may be environmental factors to manipulate the action of the focal enzymes (CBG to THC) such as nutrients, lighting, stress. Perhaps starving the plant of certain amino acids might work?

In any event, professionals from around the web are predicting we’ll see high CBG strains = 5%+ in the near future.

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THE LEGAL STATUS OF CBG

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CBG itself a Scheduled substance in the US, Canada, Europe and the rest of “the free world”.

However, extracts of any component of the cannabis plant are illegal in many areas. Today, Cannabinoids THC and CBD from cannabis plant are Schedule I controlled substances, laughably in the same class as heroin, crack and other dangerous narcotics.

CBG and other cannabinoids are left alone for now, however, if its use goes viral, the reflex action of the DEA, based on precedent with the non-psychoactive CBD, is to label it Schedule I, despite having no psychoactive effects, low in toxicity, is a naturally occurring substance and it may be highly medicinal.

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FURTHER READING

CBG coming soon? You won’t find many CBG marijuana strains currently on the market, but thanks to breeders like those at TGA genetics Subcool Seeds, the breed Mikey Kush exists. Mikey Kush strain is a Sativa-dominant strain testing with high levels of CBG and THC levels of 28.6%. CBG marijuana strains are becoming more available in Europe, and will most likely start to be seen on the shelves in North America soon. Research will surely continue, and as public interest increases, growers will be encouraged to produce high-CBG strains themselves.

You won’t find many CBG marijuana strains currently on the market, but thanks to breeders like those at TGA genetics Subcool Seeds, the breed Mikey Kush exists. Mikey Kush strain is a Sativa-dominant strain testing with high levels of CBG and THC levels of 28.6%. CBG marijuana strains are becoming more available in Europe, and will most likely start to be seen on the shelves in North America soon. Research will surely continue, and as public interest increases, growers will be encouraged to produce high-CBG strains themselves.

CANNABIGEROL (CBG) – BETTER THAN CBD? The Stem Cell Cannabinoid

“Many of us are cannabinoid deficient. A multitude of disorders and their symptoms come come from a deficiency… CBG, the stem molecule which quickly converts to CBD, THC and other cannabinoids. CBG might turn out to be the most medicinal of the lot .”

  • Control fight and flight (stress, anxiety, anger, energy)

  • Suppression of release of norepinephrine (noradrenaline)

  • Stimulates High blood pressure dropping to low

  • Constriction of certain arteries, heart (coronary artery)

  • Constriction of some vascular smooth muscle, veins

  • Decrease motility of smooth muscle in the gastrointestinal tract

  • Inhibition of lipolysis, the breakdown of complex fats (lipids) into fatty acids

  • Facilitates cognition, activity in the prefrontal cortex (PFC; working memory, attention, executive functioning, etc.)

  • Sedative effects and analgesia effects

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CBG has been shown to :

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  • Relieves pain.

  • Slow bacterial growth especially in certain species

  • Reduces seizures and convulsions.

  • Reduces inflammation systemically

  • Induce sleep

  • Inhibits cancer cell growth

  • Promotes bone growth.

  • Stimulate growth of new brain cells

Conditions under Study:

  • Glaucoma:

  • Inflammatory Bowel Disease

  • Anti-Inflammatory Disorders

  • Epilepsy

  • Chronic Pain

Did we miss anything? Lol.

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